Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease
Identifieur interne : 001A87 ( Main/Exploration ); précédent : 001A86; suivant : 001A88Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease
Auteurs : Mihai Roca [Italie, Roumanie] ; Alessia Verduri [Italie] ; Lorenzo Corbetta [Italie] ; Enrico Clini [Italie] ; Leonardo M. Fabbri [Italie] ; Bianca Beghé [Italie]Source :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 2013-05.
English descriptors
- Teeft :
- Acute decompensation, Acute events, Acute exacerbation, Acute exacerbations, Airway, Angina pectoris, Arterial chemoreceptors, Asthma, Atrial, Bronchiectasis, Brosis, Cardiovascular, Chemoreceptor, Chronic diseases, Chronic heart failure, Clinical investigation, Clinical investigation journal foundation exacerbations, Comorbidities, Concomitant, Copd, Copd exacerbation, Copd exacerbations, Copd patients, Crit, Cytokine, Decompensation, Depressive symptoms, Dysfunction, Dyspnoea, Ecopd, Edinburgh artery study, Elevation, Embolism, Endothelial, Epithelial injury, European journal, Exacerbation, General population, Heart failure, Hypercapnia, Hypertension, Hypoxaemia, Infarction, Ischaemic, Ischaemic heart disease, Metabolic syndrome, Modena, Mucus hypersecretion, Muscle proprioceptors, Myocardial, Myocardial infarction, Myocardial ischaemia, Obstruction, Oedema, Overlap syndrome, Oxidative, Oxidative stress, Pathogenic link, Pulmonary disease, Pulmonary embolism, Pulmonary oedema, Rars, Receptor, Reggio emilia, Respir, Respir crit care, Respiratory diseases, Respiratory muscles, Respiratory symptoms, Roca, Severe ecopd, Stichting european society, Stretch receptors, Symptom, Syndrome, Systemic, Systemic consequences, Systemic effects, Thorax, Vagal receptors, Ventricular, Viral infections, Willebrand factor.
Abstract
Exacerbations of chronic obstructive respiratory disease (ECOPD) are acute events characterized by worsening of the patient's respiratory symptoms, particularly dyspnoea, leading to change in medical treatment and/or hospitalisation. AECOP are considered respiratory diseases, with reference to the respiratory nature of symptoms and to the involvement of airways and lung. Indeed respiratory infections and/or air pollution are the main causes of ECOPD. They cause an acute inflammation of the airways and the lung on top of the chronic inflammation that is associated with COPD. This acute inflammation is responsible of the development of acute respiratory symptoms (in these cases the term ECOPD is appropriate). However, the acute inflammation caused by infections/pollutants is almost associated with systemic inflammation, that may cause acute respiratory symptoms through decompensation of concomitant chronic diseases (eg acute heart failure, thromboembolism, etc) almost invariably associated with COPD. Most concomitant chronic diseases share with COPD not only the underlying chronic inflammation of the target organs (i.e. lungs, myocardium, vessels, adipose tissue), but also clinical manifestations like fatigue and dyspnoea. For this reason, in patients with multi‐morbidity (eg COPD with chronic heart failure and hypertension, etc), the exacerbation of respiratory symptoms may be particularly difficult to investigate, as it may be caused by exacerbation of COPD and/or ≥ comorbidity, (e.g. decompensated heart failure, arrhythmias, thromboembolisms) without necessarily involving the airways and lung. In these cases the term ECOPD is inappropriate and misleading.
Url:
DOI: 10.1111/eci.12064
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002023
- to stream Istex, to step Curation: 002023
- to stream Istex, to step Checkpoint: 000365
- to stream Main, to step Merge: 001A97
- to stream Main, to step Curation: 001A87
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease</title><author><name sortKey="Roca, Mihai" sort="Roca, Mihai" uniqKey="Roca M" first="Mihai" last="Roca">Mihai Roca</name></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name></author><author><name sortKey="Corbetta, Lorenzo" sort="Corbetta, Lorenzo" uniqKey="Corbetta L" first="Lorenzo" last="Corbetta">Lorenzo Corbetta</name></author><author><name sortKey="Clini, Enrico" sort="Clini, Enrico" uniqKey="Clini E" first="Enrico" last="Clini">Enrico Clini</name></author><author><name sortKey="Fabbri, Leonardo M" sort="Fabbri, Leonardo M" uniqKey="Fabbri L" first="Leonardo M." last="Fabbri">Leonardo M. Fabbri</name></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B9B198B8F8F96B350038CF071BA7B510853332E2</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/eci.12064</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-93DPVQDM-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002023</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002023</idno><idno type="wicri:Area/Istex/Curation">002023</idno><idno type="wicri:Area/Istex/Checkpoint">000365</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000365</idno><idno type="wicri:doubleKey">0014-2972:2013:Roca M:mechanisms:of:acute</idno><idno type="wicri:Area/Main/Merge">001A97</idno><idno type="wicri:Area/Main/Curation">001A87</idno><idno type="wicri:Area/Main/Exploration">001A87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease</title><author><name sortKey="Roca, Mihai" sort="Roca, Mihai" uniqKey="Roca M" first="Mihai" last="Roca">Mihai Roca</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Roumanie</country><wicri:regionArea>Faculty of Medicine, Department of Pneumology, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Iasi</wicri:regionArea><wicri:noRegion>Iasi</wicri:noRegion></affiliation></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Corbetta, Lorenzo" sort="Corbetta, Lorenzo" uniqKey="Corbetta L" first="Lorenzo" last="Corbetta">Lorenzo Corbetta</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, University of Firenze, Firenze</wicri:regionArea><wicri:noRegion>Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Clini, Enrico" sort="Clini, Enrico" uniqKey="Clini E" first="Enrico" last="Clini">Enrico Clini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Pulmonary Rehabilitation, Villa Pineta Hospital, Pavullo</wicri:regionArea><wicri:noRegion>Pavullo</wicri:noRegion></affiliation></author><author><name sortKey="Fabbri, Leonardo M" sort="Fabbri, Leonardo M" uniqKey="Fabbri L" first="Leonardo M." last="Fabbri">Leonardo M. Fabbri</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Clinical Investigation</title><title level="j" type="alt">EUROPEAN JOURNAL OF CLINICAL INVESTIGATION</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><biblScope unit="vol">43</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="510">510</biblScope><biblScope unit="page" to="521">521</biblScope><biblScope unit="page-count">12</biblScope><date type="published" when="2013-05">2013-05</date></imprint><idno type="ISSN">0014-2972</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute decompensation</term><term>Acute events</term><term>Acute exacerbation</term><term>Acute exacerbations</term><term>Airway</term><term>Angina pectoris</term><term>Arterial chemoreceptors</term><term>Asthma</term><term>Atrial</term><term>Bronchiectasis</term><term>Brosis</term><term>Cardiovascular</term><term>Chemoreceptor</term><term>Chronic diseases</term><term>Chronic heart failure</term><term>Clinical investigation</term><term>Clinical investigation journal foundation exacerbations</term><term>Comorbidities</term><term>Concomitant</term><term>Copd</term><term>Copd exacerbation</term><term>Copd exacerbations</term><term>Copd patients</term><term>Crit</term><term>Cytokine</term><term>Decompensation</term><term>Depressive symptoms</term><term>Dysfunction</term><term>Dyspnoea</term><term>Ecopd</term><term>Edinburgh artery study</term><term>Elevation</term><term>Embolism</term><term>Endothelial</term><term>Epithelial injury</term><term>European journal</term><term>Exacerbation</term><term>General population</term><term>Heart failure</term><term>Hypercapnia</term><term>Hypertension</term><term>Hypoxaemia</term><term>Infarction</term><term>Ischaemic</term><term>Ischaemic heart disease</term><term>Metabolic syndrome</term><term>Modena</term><term>Mucus hypersecretion</term><term>Muscle proprioceptors</term><term>Myocardial</term><term>Myocardial infarction</term><term>Myocardial ischaemia</term><term>Obstruction</term><term>Oedema</term><term>Overlap syndrome</term><term>Oxidative</term><term>Oxidative stress</term><term>Pathogenic link</term><term>Pulmonary disease</term><term>Pulmonary embolism</term><term>Pulmonary oedema</term><term>Rars</term><term>Receptor</term><term>Reggio emilia</term><term>Respir</term><term>Respir crit care</term><term>Respiratory diseases</term><term>Respiratory muscles</term><term>Respiratory symptoms</term><term>Roca</term><term>Severe ecopd</term><term>Stichting european society</term><term>Stretch receptors</term><term>Symptom</term><term>Syndrome</term><term>Systemic</term><term>Systemic consequences</term><term>Systemic effects</term><term>Thorax</term><term>Vagal receptors</term><term>Ventricular</term><term>Viral infections</term><term>Willebrand factor</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exacerbations of chronic obstructive respiratory disease (ECOPD) are acute events characterized by worsening of the patient's respiratory symptoms, particularly dyspnoea, leading to change in medical treatment and/or hospitalisation. AECOP are considered respiratory diseases, with reference to the respiratory nature of symptoms and to the involvement of airways and lung. Indeed respiratory infections and/or air pollution are the main causes of ECOPD. They cause an acute inflammation of the airways and the lung on top of the chronic inflammation that is associated with COPD. This acute inflammation is responsible of the development of acute respiratory symptoms (in these cases the term ECOPD is appropriate). However, the acute inflammation caused by infections/pollutants is almost associated with systemic inflammation, that may cause acute respiratory symptoms through decompensation of concomitant chronic diseases (eg acute heart failure, thromboembolism, etc) almost invariably associated with COPD. Most concomitant chronic diseases share with COPD not only the underlying chronic inflammation of the target organs (i.e. lungs, myocardium, vessels, adipose tissue), but also clinical manifestations like fatigue and dyspnoea. For this reason, in patients with multi‐morbidity (eg COPD with chronic heart failure and hypertension, etc), the exacerbation of respiratory symptoms may be particularly difficult to investigate, as it may be caused by exacerbation of COPD and/or ≥ comorbidity, (e.g. decompensated heart failure, arrhythmias, thromboembolisms) without necessarily involving the airways and lung. In these cases the term ECOPD is inappropriate and misleading.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Roumanie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Roca, Mihai" sort="Roca, Mihai" uniqKey="Roca M" first="Mihai" last="Roca">Mihai Roca</name></noRegion><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><name sortKey="Clini, Enrico" sort="Clini, Enrico" uniqKey="Clini E" first="Enrico" last="Clini">Enrico Clini</name><name sortKey="Clini, Enrico" sort="Clini, Enrico" uniqKey="Clini E" first="Enrico" last="Clini">Enrico Clini</name><name sortKey="Corbetta, Lorenzo" sort="Corbetta, Lorenzo" uniqKey="Corbetta L" first="Lorenzo" last="Corbetta">Lorenzo Corbetta</name><name sortKey="Fabbri, Leonardo M" sort="Fabbri, Leonardo M" uniqKey="Fabbri L" first="Leonardo M." last="Fabbri">Leonardo M. Fabbri</name><name sortKey="Fabbri, Leonardo M" sort="Fabbri, Leonardo M" uniqKey="Fabbri L" first="Leonardo M." last="Fabbri">Leonardo M. Fabbri</name><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name></country><country name="Roumanie"><noRegion><name sortKey="Roca, Mihai" sort="Roca, Mihai" uniqKey="Roca M" first="Mihai" last="Roca">Mihai Roca</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B9B198B8F8F96B350038CF071BA7B510853332E2
|texte= Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease
}}
| This area was generated with Dilib version V0.6.33. |  |